Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population

Authors

  • Anurag Yadav Department of Biochemistry, MNR Medical College & Hospital, Sangareddy, Telangana, India
  • L G Nandakumar Professor & Diabetologist, Department of Physiology, MNR Medical College & Hospital
  • Anmol Manaswini Golla Yadav Department of General Medicine, Government Medical College & Hospital, Sangareddy, Telangana, India
  • Srivats Golla Yadav Sidhi Vinayaka Hospital, Sangareddy, Telangana, India
  • Kaveri N Karewad Sidhi Vinayaka Hospital, Sangareddy, Telangana, India

DOI:

https://doi.org/10.21776/ub.crjim.2023.004.01.2

Keywords:

Obesity, Telomere, Leptin, Body Mass Index

Abstract

Background: Obesity is a prominent avoidable cause of mortality and a growing health concern in both adults and children throughout the world. The study's goal is to measure leucocyte telomere length and its relationship with leptin throughout the BMI spectrum.

Material & Method: This cross sectional study was conducted among patients attending tertiary care hospital fulfilling the inclusion criteria. The serum taken from these samples was numbered and sent to the lab in an ice box for Leptin and Telomere length analysis. Telomere length was measured in leukocytes using the qPCR method.

Result: Total of 360 patients with mean age of the patients 47.84±15.84yrs, equally distributed in age group of 25-39yrs, 40-54yrs and >=55yrs of age. A significant negative strength of association of BMI with telomere length (r=-0.21, p<0.05) and a significant association of waist to hip ratio with telomere length (r=0.24, p<0.05). No significant relation between telomere length with the serum level of Leptin (r=0.09, p=0.386). 

Conclusion: The mean Telomere length correlated negatively with BMI and age. In the current investigation, leptin had no significant connection with telomere length.

Author Biographies

L G Nandakumar, Professor & Diabetologist, Department of Physiology, MNR Medical College & Hospital

Professor & Diabetologist, Department of Physiology, MNR Medical College & Hospital

Anmol Manaswini Golla Yadav, Department of General Medicine, Government Medical College & Hospital, Sangareddy, Telangana, India

Department of General Medicine, Government Medical College & Hospital, Sangareddy, Telangana, India.

Srivats Golla Yadav, Sidhi Vinayaka Hospital, Sangareddy, Telangana, India

Sidhi Vinayaka Hospital, Sangareddy, Telangana, India.

Kaveri N Karewad, Sidhi Vinayaka Hospital, Sangareddy, Telangana, India

Department of Physiology, MNR Medical College & Hospital, Sangareddy, Telangana, India

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Published

2023-05-25

How to Cite

Yadav, A., Nandakumar, L. G., Golla Yadav, A. M., Golla Yadav, S., & Karewad, K. N. (2023). Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population. Clinical and Research Journal in Internal Medicine, 4(1), 358–365. https://doi.org/10.21776/ub.crjim.2023.004.01.2

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Original Article