Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population
Keywords:Obesity, Telomere, Leptin, Body Mass Index
Background: Obesity is a prominent avoidable cause of mortality and a growing health concern in both adults and children throughout the world. The study's goal is to measure leucocyte telomere length and its relationship with leptin throughout the BMI spectrum.
Material & Method: This cross sectional study was conducted among patients attending tertiary care hospital fulfilling the inclusion criteria. The serum taken from these samples was numbered and sent to the lab in an ice box for Leptin and Telomere length analysis. Telomere length was measured in leukocytes using the qPCR method.
Result: Total of 360 patients with mean age of the patients 47.84±15.84yrs, equally distributed in age group of 25-39yrs, 40-54yrs and >=55yrs of age. A significant negative strength of association of BMI with telomere length (r=-0.21, p<0.05) and a significant association of waist to hip ratio with telomere length (r=0.24, p<0.05). No significant relation between telomere length with the serum level of Leptin (r=0.09, p=0.386).
Conclusion: The mean Telomere length correlated negatively with BMI and age. In the current investigation, leptin had no significant connection with telomere length.
Clemente DBP, Maitre L, Bustamante M, Chatzi L, Roumeliotaki T, Fossati S, et al. Obesity is associated with shorter telomeres in 8 year-old children. Sci Rep. 2019;9(1):18739.
Khosravaniardakani S, Bokov DO, Mahmudiono T, Hashemi SS, Nikrad N, Rabieemotmaen S, et al. Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis. Front Nutr. 2022;9:1–11.
Njajou OT, Cawthon RM, Blackburn EH, Harris TB, Li R, Sanders JL, et al. Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes. 2012;36(9):1176–9.
Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152(2):93–100.
Njajou O, Cawthon R, Blackburn E, Harris T, Li R, Sanders J, et al. Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes (Lond). 2011;36:1176–9.
Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab. 1997;82(4):1293–300.
Gielen M, Hageman GJ, Antoniou EE, Nordfjall K, Mangino M, Balasubramanyam M, et al. Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. Am J Clin Nutr. 2018;108(3):453–75.
Paltoglou G, Raftopoulou C, Nicolaides NC, Genitsaridi SM, Karampatsou SI, Papadopoulou M, et al. A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program Is Associated with Increased Leukocyte Telomere Length in Children and Adolescents with Overweight and Obesity. Nutrients. 2021;13(8):2682–6.
KrishnaKuchipudi GS, Prabhu M. Study of Association of Leptin and Leucocyte Telomere Length with Body Mass Index in Adult Indian Population a One Year Cross Sectional Study. J Assoc Physicians India. 2022;70(4):11–2.
Hiyama E, Hiyama K. Telomere and telomerase in stem cells. Br J Cancer. 2007;96(7):1020–4.
Qiang JK, Lipscombe LL, Lega IC. Association between diabetes, obesity, aging, and cancer: review of recent literature. Transl Cancer Res. 2020;9(9):5743–59.
Shin Y-A. How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging. J Obes Metab Syndr. 2019;28(2):92–104.
Vaiserman A, Krasnienkov D. Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives. Front Genet. 2021;11:1–20.
Shammas MA. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care. 2011;14(1):28–34.
Victorelli S, Passos JF. Telomeres and Cell Senescence - Size Matters Not. EBioMedicine. 2017;21:14–20.
Piplani S, Alemao NN, Prabhu M, Ambar S, Chugh Y, Chugh SK. Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease. Indian Heart J. 2018;70 Suppl 3(Suppl 3):S173–6.
Buxton JL, Walters RG, Visvikis-Siest S, Meyre D, Froguel P, Blakemore AIF. Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length. J Clin Endocrinol Metab. 2011;96(5):1500–5.
Al-Attas OS, Al-Daghri N, Bamakhramah A, Shaun Sabico S, McTernan P, Huang T-K. Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatr. 2010;99(6):896–9.
Valdes A, Andrew T, Gardner J, Kimura M, Oelsner E, Cherkas L, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366(9486):662–4.
Diaz VA, Mainous AG, Player MS, Everett CJ. Telomere length and adiposity in a racially diverse sample. Int J Obes. 2010;34(2):261–5.
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